10 results
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
donor (apheresis) platelets ... - Allergic ... recipients w/ IgA deficiency ... , due to anti-platelet ... coagulopathy & ↑bleeding
Thromboelastography (trademarked as TEG)
 • Graphical representation of the fibrin polymerization process
 • Point-of-care anti-coagulation monitoring
determining if transfusion ... algorithms and ... reduce number of transfusions ... amplitude • If ↓ → platelet ... platelets LY30
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Allergic reaction ... recipients w/ IgA deficiency ... , due to anti-platelet ... common following platelet ... coagulopathy & ↑bleeding
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... Differential #Diagnosis #Algorithm
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
When the specific allergen ... cellular antigen, leading ... to complement activation ... destruction after transfusion ... Complement activation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
incompatible blood transfusion ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... thrombopoietin deficiency ... hydration • RBC transfusion
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... Differential Diagnosis Algorithm ... Acute hemolysis, deficiency ... post-splenectomy, Exercise, Allergic ... Thrombocytosis #Platelets
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
cell antigens, leading ... to complement activation ... Examples: Acute transfusion ... they activate complement ... reactions #types #allergy
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... inhibitor (C1-INH) Deficiency ... Testing Algorithm ... #Testing #Algorithm ... #allergy #diagnosis
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
current treatment algorithm ... repeated red cell transfusions ... neutrophils or platelets ... an infection or bleeding ... #algorithm #hematology