19 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... antibiody -> Immune Complex ... Formation - Complement ... > Incr Immune Complex ... TerrierBen #Hypocomplementemic
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... immunofluorescence Immune Complex ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tracts Immune Complex ... tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Differential Diagnosis Algorithm ... perfringens - Complement-Mediated ... Drug-induced immune-complex ... #Causes #Hematology
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
Causes of Seizures ... Differential Diagnosis Algorithm ... Focal: Simple, Complex ... malformation, Aneurysm, Vasculitis ... #Causes #neurology
Causes of Dyspnea - Differential Diagnosis Algorithm
Cardiac:
 • Dysrhythmia
 • Ischemia
 • Cardiomyopathy
 • Valvular disease
Causes of Dyspnea ... Differential Diagnosis Algorithm ... hypertension • Vasculitis ... Pleura: • Pleural effusion ... #Causes
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... adhesion of IgA complexes ... Formation of immune complexes ... Activation of complement ... periumbilical region), nausea
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... pauci-immune GN Immune Complex ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis
Chest Pain - Differential Diagnosis Algorithm
Cardiovascular Causes:
 - Outflow Obstruction
     • Aortic
Differential Diagnosis Algorithm ... • Pleural Effusion ... • Herpes Simplex ... Differential #Diagnosis #Algorithm ... #causes