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diagnosis differential rheumatology causes nephrology pulmonary aki acute classification erythematosus management sle syndrome syndromes systemic acutekidneyinjury champs cryoglobulinemia cryoglobulins hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... Erythematosus (total 50, renal ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... • Urinalysis (Renal
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Diagnosis Framework Diffuse ... rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... - Normal Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... #Vasculitis #differential ... #diagnosis #algorithm
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Definition: Diffuse ... alveolar hemorrhage + Glomerulonephritis ... ANCA-positive vasculitis ... Complex: Systemic lupus ... anti-CCP • CXR (diffuse
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Differential Diagnosis Algorithm ... • Bronchitis Diffuse ... • Pulmonary Vasculitis ... Malignancy Pulmonary Vasculitis ... • Lupus Erythematosus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... disease (30%): Glomerulonephritis ... Thrombocytopenia #Lupus
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... failure (glomerulonephritis ... palpable purpura 2/2 vasculitis ... capillaritis leading to diffuse ... hemorrhage (DAH) • Diffuse
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... at least 50% Renal ... Rapidly Progressive Glomerulonephritis ... IgA, post-strep, lupus ... Sjögren) Post-Renal
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
protein/Cr - Renal ... - 45% - Pre-renal ... related) - Glomerulonephritis ... or vasculitis — ... Nephrology #Diagnosis #Algorithm
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