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differential rheumatology causes dermatology sle classification erythematosus alopecia hairloss vasculitis ana antibodies antinuclear criteria management skinrash arthritis champs comparison cryoglobulinemia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... • Nucleolar: Diffuse ... Antibodies #ANA #patterns ... #rheumatology # ... diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
significant • Pattern ... : The ANA patterns ... • Nucleolar: Diffuse ... #rheumatology # ... diagnosis #differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Algorithm Reactive ... • Systemic ... Lupus Erythematosus ... #Hematology #Oncology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... pericarditis • Hematologic ... anticoagulant • Complement ... Criteria #SLE #Systemic ... #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 80% - Low complement ... #Diagnosis #Management ... #Summary #rheumatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... Algorithm DIFFUSE ... planopilaris Pattern ... • Discoid lupus ... #Algorithm #causes
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... anticoagulant - Low complement ... hemolytic anemia #Diagnosis ... #Rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
lupus erythematosus ... - (C-ANCA) pattern ... - (P-ANCA) pattern ... against MPO • Complement ... #rheumatology #
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