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diagnosis differential rheumatology management dermatology systemic vasculitis classification erythematosus hematology nephrology alopecia diffuse disorders druginduced hairloss msk neurology obgyn obstetrics
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... 90% - Low complement ... Discontinuation of causal ... Erythematosus (SLE ... 80% - Low complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... RNP antibodies, Complement
Causes of Recurrent Pregnancy Loss - Differential Diagnosis Algorithm Environmental: • Toxin (organic solvents, mercury, lead) •
Causes of Recurrent ... Differential Diagnosis Algorithm ... Antiphospholipid syndrome ... • Lupus anticoagulant ... #Causes #Obstetrics
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... vasculitis, and SLE
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Differential Diagnosis Algorithm ... arthritis - (Reiter’s syndrome ... Polyarthritis • Systemic Lupus ... with Systemic Lupus ... Erythematosus (SLE
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... • Hepatorenal syndromes ... IgA, post-strep, lupus ... legionella) • Immune (lupus ... #Causes
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