13 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody Testing ... ARUPConsult @ARUPLabs #ANA ... Antinuclear #Antibody #Testing ... #differential # ... diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... • Nucleolar: Diffuse ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... Patterns and Associated ... • Nucleolar: Diffuse ... #patterns #rheumatology ... #diagnosis #differential
Algorithm for nodular pattern
The algorithm to distinguish perilymphatic, random and centrilobular nodules is the following:
- Look
Algorithm for nodular ... pattern The algorithm ... often easiest to see ... the nodules are diffuse ... MultipleNodules #Nodules #Differential
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
: • SLE, SSc, ... : • SjS, SLE, DM ... ARUPConsult @ARUPLabs #ANA ... #differential # ... diagnosis #rheumatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
and Focal) Differential ... Diagnosis Algorithm ... planopilaris Pattern ... #Differential # ... Diagnosis #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
hypocomplementemia ... ) pattern: antibodies ... ) pattern: is usually ... against MPO • Complement ... SLE) • Urinalysis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... diffuse peritonitis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Diagnosis Algorithm ... lymphadenopathy more diffuse ... involvement, irregular pattern ... pathophysiology #Hematology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody Testing ... Cytoplasmic Patterns ... ARUPConsult @ARUPLabs #ANA ... #differential # ... diagnosis #rheumatology