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diagnosis differential rheumatology lupus management nephrology hematology erythematosus workup cardiology classification glomerulonephritis neurology table thrombocytopenia acute aki bruising dermatology druginduced
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... , and SLE) • Urinalysis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... in drug-induced SLE ... ) • Systemic sclerosis ... Vasculitis: • ... Renal-limited vasculitis
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... Classification #ANCA ... #Differential #Algorithm
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
glomerulonephritis 90%: - ANCA ... Double Positive (ANCA ... anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... - Normal Complement
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... diseases, such as SLE ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Workup: - ANA ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... cytoplasmic antibodies; SLE ... , systemic lupus ... Glomerulonephritis #Algorithm
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... • Scleroderma (Systemic ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
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