18 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... , and SLE) • Urinalysis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... Splenomegaly - CTD (SLE ... /HSP • Cryoglobulinemia ... Associated - SLE
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... and ankles) #HSP ... HenochScholeinPurpura #Pathophysiology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Autoimmune • ITP • SLE ... HUS • DIC • Vasculitis ... #Causes #Hematology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Differential Diagnosis Algorithm ... (MPA) • SLE ... • HSP ... Differential #Diagnosis #Algorithm
Causes of Polyneuropathy - Differential Diagnosis Algorithm
 • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency
 •
Causes of Polyneuropathy ... Differential Diagnosis Algorithm ... Paraneoplastic, CTD (SLE ... RA, Sjogren’s), Vasculitis ... #causes #neurology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Erythematosus (SLE ... Osteonecrosis Esp ... Myopathy (Also caused ... Erythematosus #SLE ... Complications #pathophysiology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% SLE ... • Low serum C4 complement ... erythematosus (SLE