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diagnosis differential renal rheumatology management pulmonary syndromes acutekidneyinjury causes classification gammopathy glomerulonephritis hsct igg4 mgrs mimics monoclonal nephrology prs rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... against MPO • Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
hemorrhage + rapidly progressive ... - Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... , Behcet's Disease
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinuria, Rapidly progressing ... is 50 years • Progressive ... immune GN (rapidly progressive ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
Kidney Injury (AKI ... - Pre-renal disease ... — 21% - AKI ... Glomerulonephritis or vasculitis ... Nephrology #Diagnosis #Algorithm
HSCT related renal disease - AKI and CKD Acute Kidney Injury: Acute GvHD 2-4, Pre renal state,
related renal disease ... - AKI and CKD ... body irradiation, Complement ... #AKI #differential ... #diagnosis #algorithm
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... life-threatening diseases ... EGPA) • Renal: (AKI ... Inflammatory eye disease ... Path: rapidly progressive
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... fibroinflammatory disease ... inflammation -> progressive ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
refers to kidney disease ... end-stage kidney disease ... tubulopathy) - Complement ... formation causing vasculitis ... function and prevent progression
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