11 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... DIC, TTP, HELLP, HUS ... cardiac valve, vasculitis ... #workup #hematology ... #testing
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Intravascular Hemolysis ... Differential Diagnosis Algorithm ... perfringens - Complement-Mediated ... MAHA (TTP, DIC, HUS ... Differential #Diagnosis #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... Cryoglobulins • HIV ... • HBV HCV •
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... thrombocytopenic purpura/hemolytic ... #Differential #Algorithm
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... temperatures by fixing complement
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... LDH - Assess for hemolysis ... or alternative complement ... for ANCA-related vasculitis ... #workup #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Kidney Injury - AKI Workup ... Algorithm and Differential ... Glomerulonephritis / Vasculits ... #Injury #AKI #Workup ... #Algorithm #Differential
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... LDH - Assess for hemolysis ... or alternative complement ... for ANCA-related vasculitis ... glomerular #disease #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hematology for workup ... blood loss, Acute hemolysis ... Rheumatologic, Vasculitides ... Differential #Diagnosis #Algorithm