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diagnosis rheumatology differential vasculitis hematology management huv urticarial workup algorithm anemia atlas bloodcell bluebloater bluebloaters champs classification comparison complement disease
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Management of Hypocomplementemic ... vasculitis 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pseudotumor 4 phenotypes ... rheumatoid factor), ± hypocomplementemia ... diagnosis #management #phenotypes
COPD phenotypes: Blue Bloaters vs. Pink Puffers The two most stereotypical forms of COPD are pink
COPD phenotypes: ... stereotypical forms of COPD ... overlap syndrome of COPD ... #Diagnosis #COPD ... BlueBloaters #Comparison #Phenotypes
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 Chronic Hypercapnic Respiratory Failure Phenotypes Pink Puffers (robust vent drive) ↑ their WOB when pulmonary mechanics gradually
Respiratory Failure Phenotypes ... Respiratory #Failure #Phenotypes ... #COPD #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia
Patterns of disease in advanced COPD Type A: Pink Puffer (Emphysema Predominant) Major complaint is dyspnea, often
disease in advanced COPD ... #COPD #Patterns ... #Phenotypes #PinkPuffer
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
McLeod blood group phenotype ... Cell Agglutinate: Cold ... anemia, Paroxysmal cold
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