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diagnosis hematology anemia causes rheumatology vasculitis classification deficiency hemolytic iron agglutinin champs cold disease extravascular fe ferritin glomerulonephritis intravascular mcv
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... Mnemonic #diagnosis #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... perfringens - Complement-Mediated ... Extravascular #Differential ... #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... disease (diverse genotypes ... #Anemia #Differential ... #Diagnosis #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... Low Mean Corpuscular ... • Bleeding • Hemolysis ... #Diagnosis #Algorithm
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... Diagnosis: • hemolytic ... • Compensated hemolysis ... younger pts) Differential ... temperatures by fixing complement
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Deficiency Anemia - Differential ... Diagnosis Algorithm ... extravascular) hemolysis ... Pregnancy, Lactation, Low ... #Diagnosis #Algorithm
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Iron Deficiency - Differential ... Diagnosis Algorithm ... Intravascular hemolysis ... Pregnancy, Lactation, Low ... Iron #Deficiency #Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... pulmonary infiltrates, hemoptysis ... infiltrates/cavities, hemoptysis ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
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