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diagnosis differential rheumatology nephrology vasculitis hematology hypertension secondary acutekidneyinjury aki cardiology champs classification extravascular hemolysis intravascular low management membranoproliferative mnemonic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... dysmorphic RBC, RBC casts ... MGPN • Complement ... nephritis, malignant HTN ... Membranoproliferative #Glomerulonephritis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... , Glomerulonephritis ... against MPO • Complement
Secondary Causes of Hypertension - Differential Diagnosis Algorithm Hypertension - BP > 140/90 (>130/80 for DM) Hypertensive urgency
Differential Diagnosis Algorithm ... Consider secondary HTN ... Parenchymal Diseases • Glomerulonephritis ... #Hypertension #HTN ... Differential #Diagnosis #Algorithm
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... perfringens - Complement-Mediated ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
rhabdo/TLS) Causes ... Liano 1996) - ATN ... related) - Glomerulonephritis ... Nephrology #Diagnosis #Algorithm ... #Causes #Differential
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm Primary (Essential) (95%) - Onset between age
and Secondary Causes ... Differential Diagnosis Algorithm ... disease - CKD, AKI, Glomerulonephritis ... Primary #Secondary #HTN ... Differential #Diagnosis #Algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Abdominal pain • HTN ... , pauci-immune glomerulonephritis ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... Xerostomia • Dental caries ... acidosis • NAGMA • Glomerulonephritis
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