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diagnosis differential hematology rheumatology causes urticarial anemia champs classification extravascular hemolysis hemolytic intravascular low management mnemonic neurology pathophysiology polyneuropathy testing
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Management of Hypocomplementemic ... (HUV) Diagnosis ... of HUV 1) Chronic ... 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... Cryoglobulins • HIV ... • HBV HCV •
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Megakaryopoiesis • B12 Deficiency ... • Folate Deficiency ... Syndrome • TTP/HUS ... • DIC • Vasculitis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Defects • G6PD deficiency ... • PK deficiency ... perfringens - Complement-Mediated ... MAHA (TTP, DIC, HUS
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... When to Consider Vasculitis ... HTN • Check: HBV ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Causes of Polyneuropathy - Differential Diagnosis Algorithm • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency •
Differential Diagnosis Algorithm ... Cirrhosis, Nutritional deficiency ... - Infectious: HIV ... RA, Sjogren’s), Vasculitis ... Differential #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... ' nucleotidase deficiency ... DIC, TTP, HELLP, HUS ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm
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