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diagnosis differential rheumatology causes hematology workup anemia classification deficiency glomerular glomerulonephritis iron management nephrology nephrotic renal testing agglutinin bleeding bruising
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... against MPO • Complement ... (Low levels mixed
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
- Anti-GBM Disease ... anti-GBM) 10%: - Low ... Complement Levels ... - Normal Complement ... , Behcet's Disease
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Differential Diagnosis Algorithm ... (not extravascular ... Structural: Celiac disease ... Pregnancy, Lactation, Low ... Differential #Diagnosis #Algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Differential Diagnosis Algorithm ... ASA) • Renal Disease ... • Steroids • Vasculitis ... • Disseminated Intravascular ... Differential #Diagnosis #Algorithm
Causes of Hypocalcemia - Differential Diagnosis Algorithm • Extravascular: Pancreatitis, surgery, acute phosphate intake and renal
Differential Diagnosis Algorithm ... • Extravascular ... Chronic Kidney Disease ... Hyperphosphatemia, Low ... #Causes #algorithm
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... ; however, an algorithmic ... diseases secondary ... disseminated gonococcal disease ... , disseminated intravascular
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