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diagnosis differential hypokalemia hyponatremia nephrotic workup alkalosis glomerulonephritis metabolic potassium rheumatology vasculitis chloride hyperkalemia intercellularshift nephritic nongap proteinuria sodium syndrome
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... formation along glomerular ... staining (lg + complement ... MGPN • Complement ... Glomerulonephritis #MPGN #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
the patient have glomerular ... hematuria (RBC casts ... Syndrome #Comparison #Algorithm ... #Nephrology #Diagnosis
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
and Diagnosis Algorithm ... • Evidence of glomerular ... → Refer to Nephrology ... if cause not identified ... Hematuria #Diagnosis #Algorithm
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
Differential Diagnosis Algorithm ... Intake: • Low ... inversely related to glomerular ... rate by tubulo-glomerular ... Pathophysiology #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Differential Diagnosis Algorithm ... • Drugs Glomerular ... #Proteinuria #Nephrology ... Differential #Diagnosis #Algorithm ... #Causes
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Differential Diagnosis Algorithm ... Atherosclerosis Glomerular ... KidneyDisease #Nephrology ... Differential #Diagnosis #Algorithm ... #Causes
Causes of Hypokalemia - Differential Diagnosis Algorithm Once pseudohypokalemia is ruled out, causes of hypokalemia can be
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... filling of bucket (low ... Differential #Diagnosis #Algorithm ... #nephrology
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