11 results
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
of Hypocomplementemic ... ) Diagnosis of ... vasculitis 3) Hypocomplementemia ... (C3 and/or C4) ... TerrierBen #Hypocomplementemic
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
Levels - C3, C4 ... • SLE C3 ↓ C4 ... → • HUS C3 ↓ ... #Levels #C3 #C4 ... #differential #diagnosis
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
- Differential Diagnosis ... Levels: SLE, Cryoglobulinemic ... hypertension - MAHA: HUS ... , atypical HUS, ... #Differential #Diagnosis
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
autoimmune like SLE ... It is complement ... need the ADAMTS13 level ... with Eculizumab (complement ... Uremic #Syndrome #diagnosis
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... CRITERIA - ANA level ... anticoagulant - Low complement ... (C3, C4, or CH50 ... #Rheumatology #SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Differential Diagnosis ... levels (C3 and ... C4) • ds-DNA: Kidney ... activity • C3 C4
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Labs/Diagnosis: ... • Low serum C4 ... complement level ... erythematosus (SLE
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... diseases, such as SLE ... Vasculitis: • Fevers ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic