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algorithm alkaline evaluation gout hepatology high hyperuricemia hypocalcemia low management nephrology phosphatase rhabdomyolysis signs symptoms thyroid treatment uricacid workup
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Addison's disease, Hyperthyroidism ... #Causes #differential ... #diagnosis #calcium ... #high #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Differential Diagnosis ... normal): • Primary Hyperparathyroidism ... Bony Mets - Calcium ... #Differential # ... #causes #endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... • Sarcoidosis (elevated ... #Causes #endocrinology ... #diagnosis #differential
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... pain • loss of secondary ... ALP -> PPi and Calcium ... Hyperlipidemia - Hypercalcemia ... Phosphatase: • Other causes
Causes of Hypocalcemia by Clinical Cause Acute illness: pancreatitis, tumor lysis, severe illness - Secondary hyperparathyroidism from
Causes of Hypocalcemia ... hyperparathyroidism ... low circulating calcium ... #Causes #Differential ... #Diagnosis #Endocrinology
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 Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Diagnosis Algorithm ... Endocrine • Hyperparathyroidism ... Sarcoidosis • Hypercalcemia ... #endocrinology ... #causes
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
1) Clinical clues ... Vit D • If all ... #workup #differential ... #diagnosis #endocrinology ... #calcium #elevated
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Diagnosis Framework ... Endocrine: Hypo/Hyperthyroidism ... Hyperuricemia • Hyponatremia ... potassium and calcium
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
thyroiditis Secondary ... ↑ T3 - Mild hypercalcemia ... #causes #diagnosis ... #differential # ... endocrinology #signs
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