16 results
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Toxic injury to BM ... Clinical Presentation ... Parvovirus B19 - EBV ... #oncology #hematology ... #diagnosis #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... fraction < 20% Differential ... hepatitis • Pulmonary ... Disease #diagnosis #management ... #treatment #rheumatology
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Pulmonary arterial ... receptor type II-like ... Chronic hemolytic anemia ... Classification #Diagnosis #Differential
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
(COVID19, CMV/EBV ... immobility • Critical ... Illness Myopathy (ICU ... Electrolytes: hypo- phos, kalemia ... #Elevated #CK #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... • Symptoms of anemia ... - Mycoplasma, EBV ... younger pts) Differential ... #hematology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... of emergency, ICU ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Imaging: CXR- pulmonary ... initiation • Differential ... organ dysfuxtion, ICU ... APML #diagnosis #management ... #hematology #oncology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess - Clinical ... Leukocytosis, anemia ... Lung Abscess Differential ... Lung #Abscess #pulmonary ... #differential #
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... #oncology #management
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
VII, X, V and II ... organ damage Clinical ... variants of both • Acral ... causes #treatment #management ... #hematology