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diagnosis nephrology urology algorithm renal blood glomerulonephritis classification comparison diseases macroscopic management membranoproliferative microscopy mpgn nephrotic nonglomerular pathology proteinuria prs
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... • Evidence of glomerular ... if cause not identified ... by UW IM Residency ... Diagnosis #Algorithm #Workup
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
Causes of Hematuria ... basement membrane disease ... == Kidney - ... #Differential # ... Urology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... ) - Loss of kidney ... disease (hematuria ... staining on IF • No EM ... Classification #Differential
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria - Differential ... basement membrane disease ... disease Renal ... #Differential # ... #urology #nephrology
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
RBC’s, RBC/WBC casts ... intrinsic renal disease ... prostatic) #Diagnosis #EM ... #IM #Urology #Hematuria ... #Algorithm #Ddxof
Causes of Hematuria - Differential Diagnosis Renal: - Glomerular - IgA Nephropathy, Thin basement membrane, Alport syndrome,
Causes of Hematuria ... Diagnosis Renal: - Glomerular ... Medullary sponge kidney ... necrosis, Sickle cell disease ... #Hematuria #Differential
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Immunofluorescence Microscopy (IM ... Electron Microscopy (EM ... ) Haematuria/nephritis ... GN • Amyloid RPGN ... #diseases #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... formation along glomerular ... (Dense deposit disease ... immune deposits on EM
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Approach to the differential ... atypical HUS; MPGN ... arbitrarily defined as urine ... because nephritic urine ... Hematuria may be
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... mononeuritis multiplex WORKUP ... : UA, Urine protein ... Goodpasture's cause ... hypercellular glomeruli
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