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diagnosis hematology algorithm management oncology classification thrombocytosis acidosis aplastic b12 celiac ck cobalamin creatine disease elevated elevation gangrenosum gastroenterology hodgkins
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... #Hematology
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Nutritional: DiabetesB12 deficiency ... • Medication-induced ... Willis via UNC IM ... Peripheral #Neuropathy #differential ... #diagnosis #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Spoon-shaped • Iron deficiency ... anemia Onycholysis ... Discoloration • Medications ... #Differential # ... Diagnosis #Algorithm #causes
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... • Reaction to Medications
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
disease • Iron-deficiency ... anemia unresponsive ... to treatment ... without discernable cause ... microscopic colitis Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... - Antithyroid medications ... Treatment:
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... immobility • Critical ... - Vit D/E deficiency ... - Medications ... #Elevated #CK #differential
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... gastric acidity, medications ... intrinsic factor, IF) Clinical ... Check for IF ab Treatment ... , can consider IM
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... perfusion - shock->treatments ... before beginning treatment ... 30mmHg) - Severe anemia ... - HIV/HAART medications
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... or folic acid deficiency ... • Copper deficiency ... blood count with differential
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