34 results
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate Dehydrogenase ... Sarcoidosis Idiosyncratic ... #LDH #Lactate #Dehydrogenase
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Management of Idiosyncratic ... acetaminophen/APAP) • Idiosyncratic ... Liver #Injury #Idiosyncratic
Drug-Induced Liver Injury - Pathophysiology
Indirect
Idiosyncratic
Direct

BWH Medicine Chiefs @BrighamChiefs

#DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Pathophysiology Indirect Idiosyncratic
Steroid Synthesis Pathway

(OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
hydroxysteroid dehydrogenase
Algorithm in Suspected Bacterial Peritonitis

 - Infographic by IDagram
@ID_agram

Runyon Criteria for Secondary Peritonitis (two of the
- and lactate dehydrodgenase
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
Pre renal AKI Idiosyncratic
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Lactate Dehydrogenase
Ashkenazi Jewish Genetic Screening Algorithm
 • Bloom syndrome
 • Canavan disease
 • Familial dysautonomia
 • Fanconi
3 • Lipoamide dehydrogenase
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
ß-hydroxysteroid dehydrogenase
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Glucose-6-phosphate dehydrogenase