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diagnosis differential management algorithm hematology causes clinical rheumatology nephrology treatment classification disease pathophysiology vasculitis workup infectiousdiseases nejm pediatrics table allergy
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Immunoglobulin A • tTG IgA ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... IgA • HLA testing
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... and polyclonal IgG
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... IgM anti-HBc is ... The presence of IgG ... infected with HBV, IgG ... and IgG anti-HBc
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Poly ( - ), IgG ... DAT Poly ( + ), IgG ... DAT Poly ( + ), IgG ... Poly ( +/- ), IgG ... DAT Poly ( + ), IgG
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... infiltration of IgG4 ... lesions - IgG4 ... Biliary Tract: IgG4 ... -2.5 g/day #IGG
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Cardiolipin Antibodies, IgG ... 1 Antibodies, IgG ... Prothrombin Antibodies, IgG ... Phosphatidylserine Antibodies, IgG ... Prothrombin Antibody, IgGa
Eosinophilic angiocentric fibrosis: IgG4-related disease of the upper aerodigestive tract. Distinctive concentric (onion-skin) perivascular fibrosis and
angiocentric fibrosis: IgG4 ... Usually >50 IgG4 ... plasma cells/HPF, IgG4 ... :IgG >40%
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
allergies Type II - IgG ... antigen - IgG ... or IgM antibody ... IgG can also mediate ... Type Ill - IgG and
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,
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