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diagnosis management differential causes treatment clinical cardiology nephrology peds ddxof hematology workup im pocus pulmonary gastroenterology radiology pediatrics aliem evaluation
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF, ... Proteins #Subtypes #algorithm
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... (rarely IgG/lgA ... and polyclonal IgG ... and polyclonal IgG ... and polyclonal IgG
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
and an IgG core ... IgM anti-HBc is ... The presence of IgG ... infected with HBV, IgG ... and IgG anti-HBc
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
allergies Type II - IgG ... antigen - IgG ... or IgM antibody ... IgG can also mediate ... Type Ill - IgG and
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Disease Testing Algorithm ... • tTG IgG and ... DGP IgGa • EMA ... IgG by IFA • DGP ... Disease #Testing #Algorithm
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
Suggested algorithm ... small (<1.5 gm/dL) IgM ... low-risk MGUS (IgG ... #MGUS #Biopsy #algorithm
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
negative with IgA ... transglutaminase (tTG) IgG ... patients with IgA ... antibody test IgG ... patients with IgA
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
IgM MGUS: • Serum ... IgM monoclonal ... myeloma Non-IgM ... or IgG isotype ... (rarely IgD or IgE
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup Algorithm ... Cardiolipin Antibodies, IgG ... 1 Antibodies, IgG ... Prothrombin Antibody, IgGa ... Hypercoagulable #Workup #Algorithm
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