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Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
• Mechanism: IgG ... Coombs positive for IgG ... • Mechanism: IgM ... hematology #diagnosis #comparison
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
- Mediators: IgG ... / IgM - Antigen ... Mechanism of Action: IgG ... /lgM antibodies ... classification #comparison
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
notice there is an IgM ... The presence of IgM ... IgM anti-HBc is ... core antibody and IgM ... ) simply means IgM
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... may be seen when IgM ... 2: Monoclonal IgM ... 25%): Polyclonal IgM ... 3: Oligoclonal IgM
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... AIHA: - 20%; IgM ... mediated - DAT: IgG
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
IgM MGUS: • Serum ... IgM monoclonal ... can progress to IgM ... myeloma Non-IgM ... (rarely IgD or IgE
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
or IgM - Cell-bound ... antigen - IgG ... or IgM antibody ... Type Ill - IgG and ... IgM - Soluble antigen
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
with small (<1.5 gm ... /dL) IgM MGUS, low-risk ... MGUS (IgG type, ... - protein <1.5 gm
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Anaphylaxis) Type II - IgG ... or IgM Cytotoxic
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