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diagnosis differential rheumatology management signs symptoms algorithm hematology purpura thrombocytopenia treatment anticonvulsants arterial aspergillus blood bruising classification druginduced edema embolism
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... necrosis), Trauma, Drugs ... Leukocytoclastic Vasculitis ... (LCV), Immune complex ... nonpalpable #palpable #Causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... • Others Non-lmmune ... HUS • DIC • Vasculitis
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
Immune Reactions ... Immunosuppressant Drugs ... Immunosuppressant #Drugs ... #Pharmacology # ... Pathophysiology
Drug-Induced Edema Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
Drug-Induced Edema ... is caused by many ... Edema #Medication #Causes ... #Differential #Pharmacology ... #Pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
Group A Strep - Drugs ... cell-mediated immune ... - Formation of immune ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune ... Goodpasture's) Pauci-immune ... Glomerulonephritis #Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Necrotizing, pauci-immune ... respiratory tracts Immune ... tract, and often causes ... • Drug Associated ... polyarteritis, drug-induced
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease, drug ... purpura • Pauci immune ... GN Immune Complex ... tract, and often causes ... viral infection, drug
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria: • Immune ... glomerulopathies • Causes ... Diagnostic of GN or vasculitis ... Postpartum • Drugs ... Differential #Diagnosis #causes
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
a dysregulated immune ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology ... Signs #Symptoms #Vasculitis
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