Imperfecta disorders wrist clinical diagnosis workup rheumatology systemic classification

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Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3

Systemic Sclerosis ... distal to elbows/wrists ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup

Major neurocognitive disorders (MNCD): Diagnosis and workup

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)

neurocognitive disorders ... 1) Clinical diagnosis ... hallucinations - Movement disorders ... Differential #Subtypes #Classification ... #Workup #Diagnosis

Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations

Clinical Classification ... heart disease Systolic ... , lenectomy Systemic ... Hypertension #PHTN #Classification ... #Diagnosis #Differential

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

activate the immune system ... Syndrome: • Clinical ... Labs/Diagnosis: ... #types #classification ... #rheumatology #

CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic

Manifestations of Systemic ... Erythematosus (SLE) Clinical ... Headache, Movement disorders ... , Seizure disorders ... CNS #neurology #rheumatology

Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells

Lymphoproliferative Disorders ... - Differential Diagnosis ... site in lymphatic system ... with lymphatic system ... #Classification

Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
• Epidemiology: 10-180/100,000, Typically Age 20-40, F:M

Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... Management #Summary #rheumatology

EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
• Constitutional domain: Fever
• Cutaneous domain: Non-scarring

EULAR/ACR Classification ... Criteria for Systemic ... Erythematosus Clinical ... Erythematosus #diagnosis ... #rheumatology

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

likely it will be clinically ... • Homogeneous: Systemic ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology ... #diagnosis #differential

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

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