178 results
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... Marrow Failure Syndromes ... Shwachman-Diamond Syndrome ... #Pancytopenia #Syndromes ... #diagnosis #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... • Anemia: macrocytic ... FOR a cause → Systematic ... #diagnosis #management ... #treatment #rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Autoimmune Diseases: • Systemic ... #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... only curative treatment ... #Management #treatment ... #hematology #oncology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... important, as early diagnosis ... and treatment can ... • Systemic lupus ... #differential #diagnosis
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
block • Sjogren syndrome ... polymyositis overlap syndrome ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology #
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... - Treatment Ulcers ... : • Treatment: ... Behcets #disease #Syndrome ... #pharmacology #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
• Homogeneous: Systemic ... ) • Speckled: Systemic ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential