1748 results
COMMONLY ENCOUNTERED MEDICATIONS THAT INCREASE OR DECREASE WARFARIN’S INTERNATIONAL NORMALIZED RATIO (INR)

#Pharmacology #Warfarin #Medications #Interactions #INR
MEDICATIONS THAT INCREASE ... OR DECREASE WARFARIN ... RATIO (INR) #Pharmacology ... Interactions #INR #Increases
Orthostatic Hypotension Management Algorithm
 • Hypovolemic?  Yes → Resuscitate
 • Volume Overloaded? No → Fludrocortisone
Pyridostigmine Non-pharmacologic ... cardiac output • Increase ... PO intake, Increase ... salt intake → Increases ... venous return and increases
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
and Inotropes - Pharmacology ... (alpha-1) • Increases ... bradycardia due to increased ... / alpha1) • Increases ... Vasopressors #Inotropes #Pharmacology
Methadone Drug-Drug Interactions
Meds that increase methadone metabolism/decrease methadone effect (INCREASED RISK FOR OPIOID WITHDRAWAL):
 • Phenytoin,
Interactions Meds that increase ... methadone effect (INCREASED ... effect (INCREASED ... Fluoroquinolones (increased ... Interactions #DDIs #pharmacology
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
alpha1 > beta 1 • Increase ... Vasopressin • V1 • Increase ... • alpha 1 • Increase ... • Inotropy > Increase ... #criticalcare #pharmacology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... cell and sodium increase ... concentrations increase ... This increase of ... CaitEKulig #Digoxin #Pharmacology
Fibrates - Gemfibrozil and Fenofibrate 
Mechanism: activates PPAR alpha
Lipid Effects:
 - Decrease TG by 30-50%
 -
Lipid Effects: - Decrease ... by 30-50% - Increase ... by 5-15% - Decrease ... statin, as this increases ... #Fenofibrate #Pharmacology
Ephedrine - Anesthesia Pharmacology
Trade Name: Ephedrine
Brand Name(s): Akovaz
Drug Type: Sympathomimetic Catecholamine
Time of Onset: Rapid
Duration of Action:
Ephedrine - Anesthesia Pharmacology ... receptors along with increased ... Cardiovascular Effects: Increases ... Akovaz #Anesthesia #Pharmacology
NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk
- Celecoxib • Increased ... in patients at increased ... for CV events • Increased ... at low doses • Increased ... selectivity #spectrum #pharmacology
Adverse Effects of NSAIDs
Prostaglandins decreased
 - Gastric mucosal damage with ulcer formation, bleeding, and perforation
 -
and H2O, edemas, increased ... Leukotrienes increased ... #SideEffects #Pharmacology