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management coccidioides coccidioidomycosis infections biliary blastomycosis candida candidemia candidiasis cholangitis cirrhosis cocci differential emergencies fever fungemia fuo guidelines hemeonc hepatology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... • CNS symptoms ... the respective fungal ... Liver biopsy • ... #diagnosis
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup ... dictated by symptoms ... Consider: Spine, CNS, liver ... #candidiasis #treatment ... #fungal #fungemia
Coccidiomycosis - Diagnosis Diagnosis: • Mildly elevated peripheral WBC, Eosinophilia (25%), Elevated ESR, Procalcitonin normal (95%) •
Diagnosis: • Mildly ... trend response to treatment ... - Can involve liver ... Puncture only if CNS symptoms ... #workup #infectiousdiseases
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Mississippi and Ohio River ... : • Direct fungal ... arthroconidia; the fungus ... ) #Mycoses #InfectiousDiseases ... #Fungal #Diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... PBC Signs and Symptoms ... or higher • Liver ... amyloidosis, Bacterial, fungal ... #workup #hepatology
Waterborne Infections - Differential Diagnosis Framework Infections that can be acquired from fresh water, brackish water, sea
- Differential Diagnosis ... biphasic • Clinical symptoms ... Meningitis - Liver ... #Differential #Diagnosis ... #InfectiousDiseases
Blastomycosis Summary Pathogen: • Dimorphic fungus - Blastomyces dermatitidis or Blastomyces gilchristii. • The fungus lives
• Dimorphic fungus ... • The fungus ... Farmer and forestry work ... #management #treatment ... #infectiousdiseases
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... > 4 days → add fungal ... work-up + empiric ... → no immediate treatment ... Oncology #HemeOnc #Diagnosis
Coccidioidomycosis (Coccidioides): Valley Fever - Summary Sheet • Morphology • Geography, Reservoir and Mode of Transmission
or excavation work ... self-limiting respiratory symptoms ... , eyes, heart, liver ... prostate • Diagnosis ... management #summary #fungal
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