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diagnosis algorithm transaminitis acute dili hepatocellular arterial biliary cholangitis cirrhosis druginduced embolism enzymes function gastroenterology hematology hepatitis idiosyncratic liverenzymes liverinjury
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... Liver Injury ... Liver Injury? ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... #induced #Liver ... #differential #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... 1000): • DILI (Drug-induced ... liver injury) ... Diagnosis #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Acute Liver Injury ... obstruction - Drug-Induced ... liver injury ... #Differential # ... Hepatology #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... Transaminitis #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... for alternative causes ... titres, ↑ IgG • Cholestatic ... #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Recreational Drugs ... #Injury #Differential ... Acute #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Others • Cholestatic ... • Others #LFTs ... #Hepatology #LiverEnzymes ... Diagnosis #Algorithm #Causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... /Liver failure ... bile ducts Differential ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Intravenous Drug ... Pregnancy • Drugs ... Syndrome, Ischemic Liver ... Hyperhomocysteinemia - Heparin-induced ... Vasculitis • Injury
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