13 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Injury Hepatocellular ... Liver Injury ... #Cholestatic #Transaminitis ... #differential #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
abnormality vs bone Bili ... injury >2 ... 2: Cholestatic injury ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... or symptoms of liver ... Calculate R-Value • Hepatocellular ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injuryliver ... Liver Injury Differential ... #Liver #Injury ... #algorithm #Transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... involvement, Kidney injury ... alternative causes • Hepatocellular ... #Injury #Diagnosis ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Thrombosis, Emboli Hepatocellular ... Acute Liver Injury ... • Iatrogenic: DILI ... diagnosis #algorithm #hepatology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Appearance of Liver ... malformation, Infantile ... , Metastasis #Liver ... diagnosis #comparison #table ... #appearance #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
ALP) • R > 5: Hepatocellular ... Cellular Destruction: Hepatocellular ... ALP: Typical of hepatocellular ... #differential #Hepatology ... #transaminitis
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... malformation, Infantile ... , Metastasis #Liver ... diagnosis #comparison #table ... #appearance #hepatology