21 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Acute Fatty Liver ... presents with coagulation ... pregnancy * Severe coagulation ... defects and liver ... AFLP #obstetrics #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
• Vasculitis Coagulation ... deficiencies Coagulation ... Iatrogenic) • Liver ... Intravascular Coagulation ... Algorithm #Causes #Hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
presents with coagulation ... Hemolysis, Elevated Liver ... pregnancy * Severe coagulation ... defects and liver ... Obstetrics #OBGyn #Hematology
Spider Angioma: Dialated superficial arterioles, most commonly associated with advanced liver disease.

Charlie Goldberg, M.D. - UCSD
with advanced liver ... Images #Clinical #Photo ... #Dermatology #Rash
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... ) • Advanced Liver ... EricsMedicalLectures/ #Coagulation ... comparison #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... is simultaneous coagulation ... DIC • Severe Liver ... treatment #management #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... Kasabach-Merritt syndrome Coagulation ... deficiency • Liver ... #nonpalpable #dermatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... intravascular coagulation ... #differential #hematology ... #coagulation