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hepatology algorithm primary cholangitis differential lfts abnormal afib antibodies anticoagulation associations autoantibodies bleed causes chads2vasc diseases elevated hasbled hematology hepatitis
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary ... Cirrhosis vs Primary ... #pbc #psc #hepatology ... #comparison
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... Pathophysiology ... #Cirrhosis #PBC
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Ducts - PBC ... , PSC, Alcoholic ... - CBD stone, Biliary ... stricture, PSC,
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary ... #Biliary #Cirrhosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis ... hepatitis: < 1 • Cirrhosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
) PSC is a chronic ... to multi-focal biliary ... asymptomatic at diagnosis ... colorectal and hepato-biliary ... #Cholangitis #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential Diagnosis ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... Duct Stone • Biliary
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
A Age >65 1 Sc ... (cirrhosis, bilirubin ... drinks/week) 1 #CHADS2 ... CHADS2VASc #HASBLED #Comparison ... Anticoagulation #AFib #Diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Dermatomyositis Anti-LKM (liver ... Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... Associations #diseases #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
processes like primary biliary ... cirrhosis (PBC) ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs
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