8029 results
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Agents Subclass, Drug ... Action, Effects, Clinical ... CARBONIC ANHYDRASE INHIBITORS ... others SGLT2 INHIBITORS
Pulmonary complications of targeted therapy
-Immune checkpoint inhibitors (e.g. pembrolizumab)
-Pneumonitis is uncommon (~5% of patients) but can
Immune checkpoint inhibitors ... associated with a clinical ... unclear if this is a drug ... #Clinical #Diagnosis
Clinically Significant Cardiovascular Drug-Drug Interactions With OTC Supplements and Herbal Products
Angiotensin-Converting Enzyme Inhibitors (ACEIs)
 • Night-blooming
Clinically Significant ... Cardiovascular Drug-Drug ... Angiotensin-Converting Enzyme Inhibitors ... Monoamine Oxidase Inhibitors ... Antiarrhythmic Drugs
Daliresp (Roflumilast) 
Indication: Reduce risk of COPD exacerbations 
Drug Class: Selective Phosphodiesterase-4 (PDE4) Inhibitor 
GOLD 2019
exacerbations Drug ... Phosphodiesterase-4 (PDE4) Inhibitor ... Roflumilast is a PDE4 inhibitor ... won’t have any clinical
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... Group A Strep - Drugs ... necrosis factor a inhibitors
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... immune deficiency, Drugs ... Anti-IFN-y and JAK inhibitors
PDE5 inhibitors are usually the drugs of first choice for erectile dysfunction.

PDE5 inhibitors enhance an erection that is
PDE5 inhibitors ... are usually the drugs ... Drug interactions ... depending on the drug ... medications #dosing #drugs
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... - Calcineurin inhibitors ... panitumumab) #Drugs
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Drugs a. ... Direct Xa inhibitors ... Specific inhibitors ... Drugs a. ... drugs e.g. direct
HIV Antiretroviral Pharmacokinetic Boosters - Ritonavir & Cobicistat 

Ritonavir & Cobicistat are 2 pharmacokinetic boosters used
are both CYP3A4 INHIBITORS ... metabolism of drugs ... and a 3A4 inhibitor ... is just a 3A4 inhibitor ... both have lots of drug