369 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... immune deficiency, Drugs ... Anti-IFN-y and JAK inhibitors ... #management #treatment
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
necrosis factor-α inhibitors ... • Injection drug ... characteristic features Clinical ... Tuberculosis Diagnosis ... With TNF Inhibitor
PDE5 inhibitors are usually the drugs of first choice for erectile dysfunction.

PDE5 inhibitors enhance an erection that is
are usually the drugs ... Drug interactions ... depending on the drug ... pharmacology #comparison #treatment ... medications #dosing #drugs
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
necrosis factor-α inhibitors ... • Injection drug ... characteristic features Clinical ... Tuberculosis Diagnosis ... With TNF Inhibitor
HIV Antiretroviral Pharmacokinetic Boosters - Ritonavir & Cobicistat 

Ritonavir & Cobicistat are 2 pharmacokinetic boosters used
boosters used in HIV treatment ... are both CYP3A4 INHIBITORS ... metabolism of drugs ... and a 3A4 inhibitor ... both have lots of drug
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... panitumumab) #Drugs ... #differential #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... drugs (e.g. direct ... Inhibitors: Non ... Prolonged #Causes #diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Drugs a. ... Direct Xa inhibitors ... Drugs a. ... drugs e.g. direct ... Prolonged #Causes #diagnosis
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #differential #diagnosis
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Xa Inhibitors - ... Rivaroxaban Oral Xa inhibitors ... patients with VTE treatment ... Although there are 4 drugs ... /ambcarerx #XaInhibitors