1526 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Direct or indirect inhibitory ... direct thrombin inhibitors ... Inhibitors: Non ... specific inhibitor ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Direct Xa inhibitors ... Specific inhibitors ... Specific inhibitors ... Inhibitors ... #differential #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
deficiency, or an inhibitor ... deficiencies and inhibitors ... Patient has a factor inhibitor ... Study #diagnosis #hematology ... pathophysiology #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
direct factor Xa inhibitors ... direct thrombin inhibitors ... Autoimmune • Factor Inhibitors ... comparison #diagnosis #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
deficiency or inhibitor ... deficiency or inhibitor ... deficiency or inhibitor ... Thromboplastin #laboratory #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
pharmacological inhibitors ... diagnosis #models #hematology ... Dabigatran #thrombin #inhibitor
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
inducers (↑) and inhibitors ... concentrations, and inhibitors ... by inducers or inhibitors ... Pglycoprotein #inducers #inhibitors ... Chemotherapy #Oncology #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Deficiency or an inhibitor ... clotting factor inhibitors ... - factor VIII inhibitor ... )* • Acquired inhibitor ... Differential #Diagnosis #Hematology
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Direct Thrombin Inhibitor ... prolonged #diagnosis #hematology
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Pharmacokinetics: • MOA: Inhibits ... activation to plasmin & inhibits ... #Pharmacology #hematology