1551 results
Reported Mechanisms and Toxicity of Investigational Treatments for SARS-COV-2
Chloroquine and Hydroxychloroquine
 • Mechanisms: Interference with ligand
• Mechanisms: Interference ... ligand binding, interference ... into cytosol, decreased ... hearing loss, GI symptoms ... • Mechanism: Interference
Stepwise approach for managing asthma in youths greater than 12 years of age and adults as
the next step if symptoms ... presence of asthma symptoms ... due to asthma symptoms ... per week, some interference ... therapy should be decreased
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Elevation == Decreased ... Asplenia Laboratory Interference ... Reduction == Increase ... HgbA1c #Laboratory #Increase ... #Decrease #Diagnosis
Eosinophilic Esophagitis (EoE) - Spectrum of Response
Non-response:
 • Histology: Persistent eosinophilia, ≥ 15 eos/hpf
 • Symptoms:
, <30% decrease ... findings, <30% decrease ... : Decreased symptoms ... , 30-90% decrease ... , >90% decrease
COMMONLY ENCOUNTERED MEDICATIONS THAT INCREASE OR DECREASE WARFARIN’S INTERNATIONAL NORMALIZED RATIO (INR)

#Pharmacology #Warfarin #Medications #Interactions #INR
MEDICATIONS THAT INCREASE ... OR DECREASE WARFARIN ... INR #Increases #Decreases
Diastolic Dysfunction Grading - Echocardiography
Grade 0  (Normal):
 • E/A >0.8, e’ > 8 cm/s, E/e’
Impaired Relaxation & Decreased ... Compliance • Mild Decrease ... /e’ 8 - 15 • Increase ... Filling • Moderate Decrease ... enlargement • Severe Decrease
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Factors (GF's) • Decrease ... Osteocytes • Increase ... Bone Resorption, Decreased ... pathophysiology #signs #symptoms
Noninvasive Positive Pressure Ventilation (NIPPV)

Expiratory & Inspiratory Positive Airway Pressure
Both increase intrathoracic pressure, which can decrease
Both can decrease ... larger VT and decreases ... In CHF, decreases ... In COPD, decreases ... Cannot tolerate decreased
Assessment of the Child with Chronic Asthma
Are there other allergic disorders?
 - Allergic rhinitis
 - Eczema,
and frequency of symptoms ... tolerance - Interference
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
alpha1 > beta 1 • Increase ... • alpha 1 • Increase ... • Inotropy > Increase ... • Inotropy, Decrease ... • Inotropy, Decrease