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rheumatology management dermatology comparison erythematosus sle systemic treatment autoantibodies cutaneous differential druginduced infectiousdiseases skin activation algorithm antinuclear arteritis arthritis associations
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... Citrullinated Peptide (CCP ... Myositis: Anti-JO-1, ... #diagnosis #associations ... #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Clinical Manifestations ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Age 20-40, F:M 9:1 ... • Clinical Manifestations ... Manifestations: - CRP ... Erythematosus #Diagnosis
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Can also be measured ... -15% If SLE is clinically ... syndromes Anti-PCNA 1- ... erythematosus #diagnosis ... table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Malignancy (e.g. hematologic ... titers > 1:80 ... Ro/La, anti-Jo-1,
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
clinical associations ... , Hypotension, shock ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... cytokines, such as IL-1 ... disease • Systemic lupus ... SJIA], systemic lupus ... Activation #Syndrome #Diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... level: (1) Can ... as opposed to 1 ... (to support a diagnosis ... and RF (if clinical
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
GrepMed Handbook Clinical ... Toxic Megacolon, Shock ... post-ABx, but can ... be community-acquired ... 10 mg/kg IV x 1
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... and 1:50,000 patients ... to 8 years Clinical ... severe community-acquired ... hypogammaglobulinemia #immunology #hematology
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