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rheumatology management dermatology lupus comparison treatment associations cutaneous differential druginduced erythematosus infectiousdiseases skin sle systemic algorithm ana antibodies antinuclear antinxp2
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Citrullinated Peptide (CCP ... Myositis: Anti-JO-1, ... diagnosis #associations ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... hepatitis Anti-CCP ... Drug-induced SLE Anti-Jo-1 ... Associations #diseases #diagnosis ... #table #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... months) and of autoantibodies ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
life Causes and clinical ... , Hypotension, shock ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
-15% If SLE is clinically ... syndromes Anti-PCNA 1- ... #Antinuclear #autoantibodies ... erythematosus #diagnosis ... table #ANA
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
GrepMed Handbook Clinical ... Toxic Megacolon, Shock ... post-ABx, but can ... be community-acquired ... 10 mg/kg IV x 1
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... -> 40 years • Can ... to 8 years Clinical ... severe community-acquired ... hypogammaglobulinemia #immunology #hematology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
can only be confirmed ... suspicion is required ... for diagnosis! ... often small (<1 ... #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... segment (at least 1- ... mg per day or 1 ... slow taper over 1- ... them, but urgent rheumatology
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