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management diagnosis infectiousdiseases pharmacology syndrome hematology acute cap nejm neurology photo pneumonia pulmonary rheumatology sepsis sirs abscess activation adjuvant algorithm
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance • Acute
Antibiotic treatment ... acquired pneumonia ... CRB65=0 7 days • Community ... acquired pneumonia ... and CRB65=1 7-10
Adjuvant therapies in critical care: steroids to treat infectious diseases - Severe Community Acquired Pneumonia
Adjuvant therapies in critical ... steroids to treat infectious ... Acquired Pneumonia ... SCAP severe community-acquired ... Pharmacology #Management #Treatment
Antibiotics for severe community-onset pneumonia Atypical coverage always - Usually azithromycin 500 mg daily - Doxycycline
severe community-onset ... piperacillin-tazobactam Septic Shock ... Hospitalization for > 1 ... - Linezolid 1 ... #Acquired #Pneumonia
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
hospitalization or antibiotics ... Community water-borne ... HIV infection or ... Consider empiric antibiotic ... Hospitalization required
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR
Septic Shock • ... recognition & treatment ... (within 1 hour) ... Broad-spectrum antibiotics ... #sepsis #sirs #shock
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
GrepMed Handbook Clinical ... Toxic Megacolon, Shock ... Epidemiology: • #1 ... post-ABx, but can be community-acquired ... 10 mg/kg IV x 1
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... and 1:50,000 patients ... to 8 years Clinical ... frequent and severe community-acquired ... infections: Pneumonia
Sepsis - Diagnosis and Management Life-threatening organ dysfunction caused by a dysregulated host response to infection SEPTIC SHOCK
host response to infection ... SEPTIC SHOCK is ... Clinical construct ... recognition and treatment ... broad spectrum antibiotics
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Egophony (May appear 1- ... aeruginosa Clinical ... 96.1% • Empiric antibiotic ... #Acquired
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
of community-acquired ... compared to other antibiotic ... classes. 1 only ... successfully in clinical ... 5 however clinical
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