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management diagnosis pharmacology acute cap infectiousdiseases pneumonia sepsis sirs algorithm antimicrobials bactrim bleeding cdi cdiff clostridioides clostridium cns coverage criteria
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance • Acute
Antibiotic treatment ... acquired pneumonia ... CRB65=0 7 days • Community ... acquired pneumonia ... and CRB65=1 7-10
Antibiotics for severe community-onset pneumonia Atypical coverage always - Usually azithromycin 500 mg daily - Doxycycline
severe community-onset ... piperacillin-tazobactam Septic Shock ... Hospitalization for > 1 ... - Linezolid 1 ... #Acquired #Pneumonia
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
hospitalization or antibiotics ... Community water-borne ... HIV infection or ... Consider empiric antibiotic ... Hospitalization required
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Toxic Megacolon, Shock ... Epidemiology: • #1 ... post-ABx, but can be community-acquired ... 10 mg/kg IV x 1 ... infectiousdiseases #IDSA #gastroenterology
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR
Septic Shock • ... recognition & treatment ... (within 1 hour) ... Broad-spectrum antibiotics ... #sepsis #sirs #shock
Sepsis - Diagnosis and Management Life-threatening organ dysfunction caused by a dysregulated host response to infection SEPTIC SHOCK
host response to infection ... SEPTIC SHOCK is ... Patients w/ septic shock ... recognition and treatment ... broad spectrum antibiotics
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Egophony (May appear 1- ... 96.1% • Empiric antibiotic ... #Pulmonary #Community ... #Acquired
Sulfonamides - Antibiotics Class Overview BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic Spectrum: Wide
Sulfonamides - Antibiotics ... choice, both for treatment ... prophylaxis), Community-acquired ... MRSA Skin infections ... #Pharmacology #Antibiotics
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
of community-acquired ... compared to other antibiotic ... classes. 1 only ... in clinical CNS infections ... of CNS infections
Orthopedic Emergencies Compartment Syndrome • An increase in compartment pressure to the point where tissue perfusion is
usually appear in 1- ... • Management: 1. ... progressive inflammatory infection ... including DM • Treatment ... - Antibiotic
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