19 results
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
steroids to treat infectious ... SCAP severe community-acquired ... respiratory distress syndrome ... InfectiousDiseases #Infections ... Pharmacology #Management #Treatment
Causes of Antibiotic Failure - Differential Diagnosis Framework
Diagnosis:
 • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Diagnosis: • Non-Infectious ... NMS, serotonin syndrome ... take 48 hrs for infections ... rxn), Secondary infection ... Infection: IV catheter
Systemic Inflammatory Response Syndrome (SIRS)
•	Non-specific (infections vs non-infectious)
•	≥2 of the following:
o	Temp >38°C or <36°C
o	HR >90 bpm
o	RR
Inflammatory Response Syndrome ... Non-specific (infections ... vs non-infectious ... host response to infection ... (within 1 hour)
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hypogammaglobulinemia -> increased infection ... history of recurrent infections ... disease • Infectious ... frequent and severe community-acquired ... infections: Pneumonia
Algorithm for the Evaluation of Acute Diarrhea (< 7 days)
Are the following present?
   1.
hospitalization or antibiotics ... Community water-borne ... HIV infection or ... Consider empiric antibiotic ... Hospitalization required
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Clostridioides Difficile Infection ... Toxic Megacolon, Shock ... nosocomial infection ... post-ABx, but can be community-acquired ... #Clostridium #Infection
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
Syndrome (STSS) ... necrosis STSS Treatment ... IVIG 1g/kg on day 1, ... day 2 + 3 BIDMC Infectious ... #Syndrome #STSS
Sulfonamides - Antibiotics Class Overview

BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic

Spectrum: Wide
choice, both for treatment ... prophylaxis), Community-acquired ... MRSA Skin infections ... Nocardiosis, Listeria infections ... patients, Salmonella infections
Sepsis - Diagnosis and Management
Life-threatening organ dysfunction caused by a dysregulated host response to infection
SEPTIC SHOCK
host response to infection ... SEPTIC SHOCK is ... Patients w/ septic shock ... recognition and treatment ... broad spectrum antibiotics
CSF Penetration of Antimicrobials

Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
of community-acquired ... classes. 1 only ... in clinical CNS infections ... susceptible CNS infections ... of CNS infections