7 results
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... of Factor IX Acquired ... Liver Disease - Alcohol ... Acute DIC - Septic shock ... comparison #diagnosis #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Kidney Failure Coagulation ... Failure Infections Alcohol-Associated ... Failure #Cirrhosis #Hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... dysfunction (16%) • Shock ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... the secondary or acquired ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... Diagnosis #Management #Hematology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... Eligibility for Treatment ... Multiorgan failure or shock ... prednisolone #Alcoholic ... Management #Algorithm #hepatology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
by uncontrolled activation ... search for and treatment ... • Secondary (Acquired ... Treatment Approach ... Diagnosis #Management #Hematology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
cirrhosis, severe alcoholic ... sympathetic + ADH activation ... Treatment Overview ... insult (e.g., alcohol ... Hepatorenal #Syndrome #Hepatology