855 results
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
ATPase pump and intracellular ... won't increase the intracellular ... for sodium and intracellular ... This increase of intracellular ... Hyperkalemia (high
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
- Shift from extracellular ... fluid to intracellular ... - Insulin (high
Hyperkalemia Management Algorithm
 • Treat the cause & optimize hemodynamics and ventilation
 • Reconsider treatment leadingto
Stabilization 2) Intracellular ... treatment #potassium #high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... Penicillin G Intracellular ... causes #potassium #high
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
negative, Facultative intracellular ... Inflammation: high
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... cells releasing intracellular ... Spontaneous if high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
phlebotomy High ... Penicillin G Intracellular ... causes #potassium #high
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
Our Extracellular ... Our Intracellular ... we introduce a high ... The high CL- content
Digoxin effect on Electrocardiogram (EKG)
Digoxin is a cardiac glycoside from the foxglove leaf
Mechanism
 - Inhibits Na-K
ATPase -> increase intracellular ... Na / extracellular ... K -> increase intracellular
Hyperkalemia Management
Pseudohyperkalemia: 1. Hemolyzed sample 2. Blood drawn from a site/line where potassium or TPN is
minutes-hour) -Shift intracellularly ... treatment #potassium #high