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diagnosis management hematology syndrome lupus differential erythematosus hemeonc systemic acidosis activation antiphospholipid apls arterial behcet cerebritis classification cns coagulation comparison
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... autoantibodies that will cause ... ischemia and/or ... CNS #neurology #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Venous Thrombosis ... Nephrotic Syndrome, Ischemic ... Liver, IBD • ... coagulation and other causes ... pathophysiology #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... versus DIL • ... Positive in 60-80% of cases ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... versus DIL • ... life-threatening • Treatment ... comparison #table #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
, - regional ischemia ... of lactate as a clinical ... again we might see ... perfusion - shock->treatments ... before beginning treatment
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
also involved), Venous ... Oral aphthae : SLE ... retinal tears, Ischemia ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
limb and bowel ischemia ... arterial and/or venous ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... DIC • Severe Liver ... Treat primary cause ... #treatment #management ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... thrombocytopenia • Liver ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
) after 5-10d, venous ... Diagnosis: • Clinical ... Confirmatory test ↑Se ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
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