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diagnosis differential liver injury transaminitis acidosis ascites chemistry classification diffuse dili druginduced elevation hearingloss hematology hepatocellular interpretation lactate lactic lad
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
20x normal - Acute ... normal - Infection (EBV ... /CMV), Alcoholic ... Liver #Injury #hepatology ... #LFTs #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... , HBV, HCV, HEV, ... EBV, CMV), Alcohol-related ... dechallenge • Acute ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... hepatitis • Drugs ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... : Alcohol, Medication ... Medication, Pregnancy, Alcoholic ... #Acute #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... exclude other causes ... : - Acute kidney ... #Algorithm #hepatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Tuberculosis • Hepatitis ... Fatigue • Acute ... #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... , HBV, HCV, HEV, ... ALT Ratios: • Alcoholic ... #hepatology
Sensorineural Hearing Loss - Differential Diagnosis Algorithm Asymmetric Sensorineural Hearing Loss: • Neoplastic (Vestibular Schwannoma) •
Toxoplasmosis, HIV ... , Syphilis, Hepatitis ... Teratogenic drugs, Alcohol ... Cardiovascular Ischemia ... #Causes
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... ALT Ratios: • Alcoholic ... #differential #Hepatology ... transaminitis #LFTs
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