11 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... , HBV, HCV, HEV, ... Hepatic ischaemia ... disorder (e.g. ascites ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Trauma: Shock liver ... • Iatrogenic: DILI ... See Updated Schema ... Diagnosis #causes ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Vascular Causes ... , HBV, HCV, HEV, ... • Iatrogenic: DILI ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Workup Algorithm ... osmolarity If cause ... cryoglobulins, hepatitis ... serology, HIV serology ... #Workup #Algorithm
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Liver disease ... - Alcoholic hepatitis ... #differential # ... hepatology #SAAG
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... develops (DIC, ascites ... infiltration) Differential ... Diagnosis: Viral Hepatitis ... #Pregnancy #hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... blood, urine and ascites ... HCV, DILI, HCC, ... #hepatology