9 results
diagnosis differential injury lfts transaminitis causes albumin chemistry druginduced gradient hepatocellular interpretation management patterns rvalue serum
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
EBV, CMV), Alcohol-related ... Hepatic ischaemia ... disorder (e.g. ascites ... ), Chronic hepatitis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... normal - Infection (EBV ... /CMV), Alcoholic ... 5-10x normal - Chronic ... #Injury #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Liver disease ... Cirrhosis - Alcoholic ... hepatitis ... - Acute fatty liver ... #differential #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Gradient (SAAG) ... Cirrhosis - Alcoholic ... hepatitis - Cardiac ... associated with bowel ischemia ... Differential #Diagnosis #hepatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Renal Failure • Liver ... Epstein-Barr Virus • Hepatitis ... • HIV Autoimmune ... Alcohol) • Drug ... #Chronic #Fatigue
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
serologies, HCV ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... blood, urine and ascites ... diseases including HBV ... HCV, DILI, HCC, ... #Algorithm #hepatology
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