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liver differential injury transaminitis hepatitisb gastroenterology hepbv phases aclf acute alcoholic chemistry cirrhosis drug druginduced failure function hepatocellular idiosyncratic induced
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... non-essential drug/HDS treatments ... , HBV, HCV, HEV, ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... Cirrhosis • Chronic ... (>1000): • DILI ... liver injury) • Ischemic ... #hepatology #transaminitis
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Management Algorithm ... Chronic Hepatitis ... #Algorithm #Diagnosis ... #Management #Treatment
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
normal - Infection (EBV ... 5-10x normal - Chronic ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... #algorithm #gastroenterology ... #hepatology
Hepatitis B Phases and Treatment Phase 1 - HBeAg+ Chronic Infection Phase 2 - HBeAg+ Chronic Hepatitis Phase 3
and Treatment ... Seroconv Occult HBV ... #HBV #HepBV #Phases ... #Treatment #Management ... #diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... , HBV, HCV, HEV, ... > 2 • NASH, Chronic ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
- Management Algorithm ... diseases including HBV ... HCV, DILI, HCC, ... #Management #Algorithm ... #hepatology
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